2022年11月消息，新加坡国家环境局（NEA）已根据《环境保护与管理法》（EPMA），将26种化学物质列为有害物质（hazardous substances, HS）进行管制，从事涉及26种化学品中任何一种的以下活动的公司必须获得HS许可证/执照：
●进口、出口、制造、销售、运输、储存和/或使用受管制化学品——需要执照（HS licence）；
●购买、储存和/或使用受管制化学品——需要许可证（HS permit）。
NEA计划监管于2023年6月生效，这些变化将在2022年12月前通报。自2023年1月1日起，在《环境保护与管理法》和《环境保护和管理（有害物质）条例》修正案公布后，NEA建议公司可开展修改或申请HS许可证/执照。
NEA管制的HS具有高度毒性、污染性，并且是难以进行生产管理和安全处置的废料。
对于具有更广泛工业用途的物质，NEA正在对这些物质构成的潜在安全和环境风险进行更详细的审查，以便在可能的情况下给予低浓度豁免。利益相关方可以在2022年11月 10日之前将相关数据（例如安全数据表、混合物/产品中存在的化学品浓度以及化学品储量）提交NEA进行审议。
目前，这26种化学物质由新加坡海关根据《化学武器（禁止）法》(CWPA)和《化学武器（禁止）条例》（CWPR）与NEA共同监管。
26种化学物质清单：
| S/N | Chemical Name | CAS Registry No. |
| 1 | O-Alkyl(≤C10, including cycloalkyl) alkyl (Me, Et, n-Pr or i-Pr)-phosphonofluoridatese.g.Sarin: O-Isopropyl methylphosphonofluoridateSoman: O-Pinacolyl methylphosphonofluoridate | 107-44-896-64-0 |
| 2 | O-Alkyl (H or ≤C 10 , including cycloalkyl) S-2-dialkyl (Me, Et, n-Pr or i-Pr)-aminoethyl alkyl (Me, Et, n-Pr or i-Pr) phosphonothiolates and corresponding alkylated or protonated saltse.g.VX: O-Ethyl S-2-diisopropylaminoethyl methyl phosphonothiolate | 50782-69-9 |
| 3 | Lewisites:Lewisite 1: 2-ChlorovinyldichloroarsineLewisite 2: Bis(2-chlorovinyl)chloroarsineLewisite 3: Tris(2-chlorovinyl)arsine | 541-25-340334-69-840334-70-1 |
| 4 | Nitrogen mustards:HN1: Bis(2-chloroethyl)ethylamineHN2: Bis(2-chloroethyl)methylamine 51-75-2HN3: Tris(2-chloroethyl)amine | 538-07-851-75-2555-77-1 |
| 5 | Saxitoxin | 35523-89-8 |
| 6 | Ricin | 9009-86-3 |
| 7 | Alkyl (Me, Et, n-Pr or i-Pr) phosphonyl difluoridese.g.DF: Methylphosphonyldifluoride | 676-99-3 |
| 8 | O-Alkyl (H or ≤C 10 , including cycloalkyl) O-2-dialkyl (Me, Et, n-Pr or i-Pr)-aminoethyl alkyl (Me, Et, n-Pr or i-Pr)-phosphonites andcorresponding alkylated or protonated saltse.g.QL: O-Ethyl O-2-diisopropylaminoethyl methylphosphonite | 57856-11-8 |
| 9 | Chlorosarin: O-Isopropyl methylphosphonochloridate | 1445-76-7 |
| 10 | Chlorosoman: O-Pinacolyl methylphosphonochloridate | 7040-57-5 |
| 11 | Р-alkyl (H or ≤C 10 , incl. cycloalkyl) N-(1-(dialkyl(≤C 10 , incl.cycloalkyl)amino))alkylidene(H or ≤C 10 , incl. cycloalkyl)phosphonamidic fluorides and corresponding alkylated or protonated saltse.g.N-(1-(di-n-decylamino)-n-decylidene)-P-decylphosphonamidic fluoride 2387495-99-8Methyl-(1-(diethylamino)ethylidene) phosphonamidofluoridate | 2387495-99-82387496-12-8 |
| 12 | O-alkyl (H or ≤C 10 , incl. cycloalkyl) N-(1-(dialkyl(≤C 10 , incl. cycloalkyl)amino))alkylidene(H or ≤C 10 , incl. cycloalkyl)phosphoramidofluoridates and corresponding alkylated or protonated saltse.g.O-n-Decyl N-(1-(di-n-decylamino)-ndecylidene)phosphoramidofluoridateMethyl (1-(diethylamino)ethylidene) phosphoramidofluoridateEthyl (1-(diethylamino)ethylidene) phosphoramidofluoridate | 2387496-00-42387496-04-82387496-06-0 |
| 13 | Methyl-(bis(diethylamino)methylene) phosphonamidofluoridate | 2387496-14-0 |
| 14 | Carbamates (quaternaries and bisquaternaries ofdimethylcarbamoyloxypyridines)Quaternaries of dimethylcarbamoyloxypyridines:1-[N,N-dialkyl(≤C10)-N-(n-(hydroxyl, cyano, acetoxy)alkyl(≤C10)) ammonio]-n-[N-(3-dimethylcarbamoxy-α-picolinyl)-N,N dialkyl(≤C10) ammonio]decane dibromide (n=1-8)e.g.1-[N,N-dimethyl-N-(2-hydroxy)ethylammonio]-10 [N- (3-dimethylcarbamoxy-α-picolinyl)-N,N dimethylammonio]decane dibromideBisquaternaries of dimethylcarbamoyloxypyridines:1,n-Bis[N-(3-dimethylcarbamoxy-α-picolyl)-N,N-dialkyl(≤C10)ammonio]-alkane-(2,(n-1)-dione) dibromide (n=2-12)e.g.1,10-Bis[N-(3-dimethylcarbamoxy-α picolyl)-N-ethyl-N-methylammonio] decane-2,9-dione dibromide | 77104-62-277104-00-8 |
| 15 | PFIB: 1,1,3,3,3-Pentafluoro-2-(trifluoromethyl) -1-propene | 382-21-8 |
| 16 | BZ: 3-Quinuclidinyl benzilate | 6581-06-2 |
| 17 | Chemicals, except for those listed in Schedule 1, containing a phosphorus atom to which is bonded one methyl, ethyl or propyl (normal or iso) group but not further carbon atomse.g.Methylphosphonyl dichlorideDimethyl methylphosphonateExemption:Fonofos: O-Ethyl S-phenyl ethylphosphonothiolothionate | 676-97-1756-79-6944-22-9 |
| 18 | Dialkyl (Me, Et, n-Pr or i-Pr) N,N-dialkyl (Me, Et, n-Pr or i-Pr)- phosphoramidates | – |
| 19 | 2,2-Diphenyl-2-hydroxyacetic acid: Benzilic acid | 76-93-7 |
| 20 | Quinuclidin-3-ol | 1619-34-7 |
| 21 | N,N-Dialkyl (Me,Et,n-Pr or i-Pr) aminoethyl- 2-chlorides and corresponding protonated salts | – |
| 22 | N,N-Dialkyl (Me, Et, n-Pr or i-Pr) aminoethane-2-thiols and corresponding protonated salts | – |
| 23 | Thiodiglycol: Bis(2-hydroxyethyl)sulfide | 111-48-8 |
| 24 | Diethyl phosphite | 762-04-9 |
| 25 | Thionyl chloride | 7719-09-7 |
| 26 | Triethanolamine | 102-71-6 |
